The number of treatment options available for head and neck cancer (HNC) has increased in the last decade thanks to advanced technologies. While current post-treatment care plans focus on functional and health conditions, there are socioeconomic determinants of quality of life that also need to be addressed. The EU-funded BD4QoL project aims to improve HNC survivors’ quality of life by developing a person-centred monitoring and follow-up plan. It will use artificial intelligence and Big Data collected from mobile devices, in combination with multi-source clinical and socioeconomic data and patients’ reported outcomes. Analysis of the quality of life indicators collected over time will facilitate early detection of risks, prevent long-term effects of treatment, and inform patients and caregivers for personalised interventions.